1. The Jews killed the prophets and the Christ whom the prophets had promised to come. (Jer 44:4-6)
    Jer 7:25, Jer 25:4, Jer 29:19, Jer 35:15, Mt 5:12, Mt 23:37, Mt 21:35-36, Acts 7:51-52, 1 Thess 2:15-16

In the Old Testament, God sent prophets to the Israelites to tell them not to do things that God hates. But the Israelites did not listen to the prophets. (Jeremiah 44:4-6, Jer 7:25, Jer 25:4, Jer 29:19, Jer 35:15)

Jeremiah 44:4 Howbeit I sent unto you all my servants the prophets, rising early and sending them, saying, Oh, do not this abominable thing that I hate.
5 But they hearkened not, nor inclined their ear to turn from their wickedness, to burn no incense unto other gods.
6 Wherefore my fury and mine anger was poured forth, and was kindled in the cities of Judah and in the streets of Jerusalem; and they are wasted and desolate, as at this day.

Jer 7:25 Since the day that your fathers came forth out of the land of Egypt unto this day I have even sent unto you all my servants the prophets, daily rising up early and sending them:

Jer 25:4 And the Lord hath sent unto you all his servants the prophets, rising early and sending them; but ye have not hearkened, nor inclined your ear to hear.

Jer 29:19 Because they have not hearkened to my words, saith the Lord, which I sent unto them by my servants the prophets, rising up early and sending them; but ye would not hear, saith the Lord.

Jer 35:15 I have sent also unto you all my servants the prophets, rising up early and sending them, saying, Return ye now every man from his evil way, and amend your doings, and go not after other gods to serve them, and ye shall dwell in the land which I have given to you and to your fathers: but ye have not inclined your ear, nor hearkened unto me.

The Israelites did not listen to the righteous, Christ who the Old Testament prophets had promised to come, but rather killed Him. (Matthew 5:12, Matthew 23:37, Matthew 21:35-36, Acts 7:51-52, 1 Thessalonians 2:15-16)

Matthew 5:12 Rejoice, and be exceeding glad: for great is your reward in heaven: for so persecuted they the prophets which were before you.

Matthew 23:37 O Jerusalem, Jerusalem, thou that killest the prophets, and stonest them which are sent unto thee, how often would I have gathered thy children together, even as a hen gathereth her chickens under her wings, and ye would not!

Matthew 21:35 And the husbandmen took his servants, and beat one, and killed another, and stoned another.
36 Again, he sent other servants more than the first: and they did unto them likewise.

Acts 7:51 Ye stiffnecked and uncircumcised in heart and ears, ye do always resist the Holy Ghost: as your fathers did, so do ye.
52 Which of the prophets have not your fathers persecuted? and they have slain them which shewed before of the coming of the Just One; of whom ye have been now the betrayers and murderers:

1 Thessalonians 2:15 Who both killed the Lord Jesus, and their own prophets, and have persecuted us; and they please not God, and are contrary to all men:
16 Forbidding us to speak to the Gentiles that they might be saved, to fill up their sins alway: for the wrath is come upon them to the uttermost.